汪俊松教授
汪俊松，男，1975年7月生，安徽无为人，博士，教授，德国洪堡学者，南京理工大学博士研究生导师，江苏省第四期“333工程”中青年科学技术带头人和2011年度教育部“新世纪优秀人才”，国家自然科学基金、中国博士后科学基金评审专家。世界中医药学会联合会中药化学专业委员会、中药上市后再评价专业委员会理事。主持德国洪堡学者研究基金，国家自然科学基金青年、面上基金，教育部新世纪优秀人才, 十一五“重大新药创制”科技重大专项候选药物研究等项目。
学习与工作经历
1992年9月-1996年7月，安徽中医学院中药系获得中药学学士学位；
1996年7月-1999年8月，安徽省中药材公司质检员；
1999年9月-2005年3月，于中科院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室进行研究并获得理学博士学位；
2005年9月-2007年1月，于韩国生命工学研究院进行博士后研究。
2007年2月-2008年2月，在世界著名的亚历山大•冯•洪堡基金会资助下作为洪堡学者在德国癌症研究中心开展研究工作；
2008年3月-2013年1月，作为海外引进人才供职中国药科大学中药学院（直聘副教授）。
2013年2月至今，南京理工大学环境与生物工程学院教授。
研究方向
1．天然药物化学研究：天然产物活性成分的提取、分离、结构鉴定、修饰及生物活性研究。；
2．中药复方研究：根据中药复方多成分、多靶点、整体作用的特点，综合运用系统科学、计算科学、非线性科学等多学科交叉融合手段处理其化学组成信息和药效活性信息，探讨其生物效应的谱效关系，构建中药复方的质量标准和评价体系。
3．代谢组学新技术新方法以及应用研究：以NMR和UPLC-QTOF-MS为主要测试手段，对生物体内内源性代谢物进行定量分析，结合模式识别和专家系统等计算分析方法寻找代谢物与生理病理变化的相对关系，探讨代谢组在药效评价、疾病诊断、环境毒理中的应用研究
主持项目
1. “重大新药创制”科技重大专项“中药前胡总香豆素抗哮喘候选药物研究”（2009ZX09103-322，2009.1—2010.12）
2. 2008国家自然科学基金青年科学基金项目“利用协同效应逆向筛选中药中肿瘤多药耐药逆转剂”（No.30801514，2009.1—2011.12）
3. 2011国家自然科学基金面上项目“黄连解毒汤治疗脑卒中的定量组分配伍研究”（No.81173526，2012.1—2015.12）
4. 2011教育部新世纪优秀人才支持计划（#NCET-11-0738，2012.1—2014.12）
5. 南京理工大学自主科研专项重大研究计划(NO.30920130112014, 2013.1—2014.12)
近五年主要文章列表
1. Li, P.#; Wei, D.D.#; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, 1H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures. Journal of Pharmaceutical and Biomedical Analysis 2015 (Accepted).
2. Lou, Y.H; Wang, J.S.*; Dong, G.; Guo, P.P.; Wei, D.D.; Xie, S.S.; Yang, M.H.; Kong, L.Y.*, The acute hepatotoxicity of tacrine explained by 1H NMR based metabolomic profiling. Toxicology Research 2015. doi: 10.1039/C5TX00096C.
3. Li, M.H.#; Ruan, L.Y.#; Liu, Y.; Xu, H. D.; Chen, T.; Fu, Y.H.; Jiang, L.; Wang, J.S.*, Insight into biological system responses in goldfish (Carassius auratus) to multiple doses of avermectin exposure by integrated 1H NMR-based metabolomics. Toxicology Research 2015, 4, 1374–1388.
4. Li, P.C.; Tao, J.; Wei, D.D.; Yang, X.; Lu, Z.G.; Deng, X.H.; Cheng, Y.; Gu, J.B.; Yang, X.J.; Wang, Z.J., Lu, Q.,* Wang, J.S.*, Yin, C.J., Serum metabolomic analysis of human upper urinary tract urothelial carcinoma. Tumor Biology 2015, doi:10.1007/s13277-015-3482-3.
5. Wei, D.D.#; Liao S.T.#; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling. RSC advances 2015, 5, 66200–66211.
6. Liu, Y.; Chen, T.; Li, M.H.; Xu, H.D.; Jia, A.Q.; Zhang, J.F.; Wang, J.S.*, 1H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus). Chemosphere 2015, 138, 537-545.
7. Dong, G.#; Wei, D.D.#; Wang, J.S.*; Guo, P.P; Li, M.H.; Yang, M.H.; Kong, L.Y.*, Study of the cardiotoxicity of Venenum Bufonis in rats using an 1H NMR-based metabolomics approach. Plos one 2015, 10(3): e0119515. doi: 10.1371/journal.pone.0119515.
8. Xiong, Y.Y. #*; Wang, J.S.#; Yu, H.; Zhang, X.L.; Miao, C.G, Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease. Immunopharmacology and Immunotoxicology 2015 , 37(3), 236-243.
9. Guo, P.P.#; Wei, D.D. #; Wang, J.S.*; Dong, G.; Zhang, Q; Yang, M.H.; Kong, L.Y.*, Chronic toxicity of crude ricinine in rats assessed by 1H NMR metabolomics analysis. RSC advances 2015, 5, 27018-27028.
10. Xu, H.D.; Wang, J.S.*; Li, M.H.; Liu, Y.; Chen, T.; Jia, A.Q.*, 1H NMR based metabolomics approach to study the toxic effects of herbicide butachlor on goldfish (Carassius auratus). Aquatic Toxicology 2015, 159, 69-80.
11. Dong G.; Wang, J.S.*; Guo, P.P; Wei D.D.; Yang, M.H.; Kong, L.Y.*, Toxicity assessment of Arisaematis Rhizoma in rats by a 1H NMR-based metabolomics approach. Molecular BioSystems 2015 , 11(2), 407-417.
12. Wei, D.D.; Wang, J.S.*; Li, M.H.; Guo, P.P.; Dong, G.; Yang, M.H.; Kong, L.Y.*, A pilot study of the onset of hepatic encephalopathy (OHE) in mice induced by thioacetamide and the protective effect of taurine by holistic metabolic characterization. Metabolomics 2015, 11 (3), 559-570.
13. Lu, Z.G.; Li, M.H.#; Wang, J.S.*; Wei, D.D.; Liu, Q.W.; Kong, L.Y.*, 1H NMR-based metabolomics study on a goldfish model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemico-Biological Interactions 2014, 223(5), 18-26.
14. Xiong, Y.Y. #*; Wang, J.S. #; Yu, H.; Zhang, X.L.; Miao, C.G.; Ma, S.T., The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacology and Immunotoxicology 2014, 36(5), 341-348.
15. Wei, D.D.#; Dong, G.#; Guo, P.P.; Wang, J.S.*; Li, M.H.; Yang, M.H.; Kong, L.Y.*, A bird's eye view of anisatin induced convulsive seizures in brain by a 1H NMR based metabolic approach. Molecular BioSystems 2014, 10, 2923-2934.
16. Guo, P.P.; J. Wang, J.S.*; Dong G.; Wei D.D.; Li, M.H.; Yang, M.H.; Kong, L.Y.*, NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats. Molecular BioSystems 2014, 10, 2426-2440.
17. Li, X.; Jia, Y.W.; Wang, J.S.*; Wang, Kelvin; Yang, M.H.; Kong, L.Y.*, 1H nuclear magnetic resonance-based metabolomics reveals sex-specific metabolic changes of gastrodin intervention in rats. Asian Pacific Journal of Tropical Medicine 2014, 7 (10), 811-818.
18. Lu, Z.G.#; Li, M.H.#; Wang, J.S.*; Wei, D.D.; Liu, Q.W.; Kong, L.Y.*, Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae. Reproductive Toxicology 2014, 47 (0), 33-41.
19. Wei D.D., Wang J.S.*, Wang P.R., Li, M.H.; Yang, M.H.; Kong, L.Y.*. Toxic effects of chronic low-dose exposure of thioacetamide on rats based on NMR metabolic profiling. Journal of Pharmaceutical and Biomedical Analysis, 2014, 98, 334-338.
20. Li, M.H.; Wang, J.S.*; Lu, Z.G.; Wei, D.D.; Yang, M.H.; Kong, L.Y.*, NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus). Aquatic Toxicology 2014, 146, 82-92.
21. Wang, P.R.; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Neuroprotective effects of Huang-Lian-Jie-Du-Decoction on ischemic stroke rats revealed by 1H NMR metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis 2014, 88, 106-116.
22. Wang, P.R.; Wang, J.S.*; Zhang, C.; Song, X.F.; Tian N.; Kong, L.Y.*, Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway. Journal of Ethnopharmacology 2013, 149 (1), 270-280.
23. Yin, P.J.#; Wang, J.S.#; Wei, D.D.; Zhang, Y.; Wang, P.R.; Wang, X.B.; Kong, L.Y.*, Simonols A and B, two novel sesqui-neolignans from the fruits of Illicium simonsii. Fitoterapia 2013, 88, 31-37.
24. Zhang, Y.; Wang, J.S.*; Wei, D.D.; Gu, Y.C.; Wang, X.B.; Kong, L.Y.*, Bioactive Terpenoids from the Fruits of Aphanamixis grandifolia. Journal of Natural Products 2013, 76 (6), 1191-1195.
25. Tian, N.; Wang, J.S.*; Wang, P.R; Song, X.F.; Yang, M.H.; Kong, L.Y.*, NMR-based metabonomic study of Chinese medicine Gegen Qinlian Decoction as an effective treatment for type 2 diabetes in rats. Metabolomics 2013, 9 (6), 1228-1242.
26. Song, X.F.; Wang, J.S.*; Wang, P.R.; Tian N.; Yang, M.H., Kong, L.Y.*, 1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet, Journal of Pharmaceutical and Biomedical Analysis 2013, 78-79, 202-210.
27. Wang, J.S.; Zhou J.; Kong, L.Y.*, Three new germacrane-type sesquiterpene stereoisomers from the flowers of Chrysanthemum indicum. Fitoterapia 2012, 83 (8), 1675-1679.
28. Zhang, M.#; Wang, J.S.#; Wang, P.R.; Oyama, M.; Luo, J.; Ito, T.; Iinuma, M.*; Kong, L.Y.*, Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities. Fitoterapia 2012, 83 (8), 1604-1609.
29. Xiong, Y.Y.#; Wang, J.S.#; Wu, F.H.; Li, J.; Kong, L.Y.*, The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma. International Immunopharmacology 2012, 14 (4), 392-400.
30. Xiong, Y.Y.#; Wang, J.S.#; Wu, F.H.; Li, J.; Zhou, L.F.; Kong, L.Y.*, Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease. European Journal of Pharmacology 2012, 683 (1-3), 316-324.
31. Guo, C.; Wang, J.S.*; Zhang, Y.; Yang, L.; Wang, P.R.; Kong, L.Y.*, Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chemical & Pharmaceutical Bulletin 2012, 60 (8), 1003-1010 (Impact Factor :1.564)
32. Wang, J.S.#; Zhang, Y.#; Wang, X.B.; Kong, L.Y.*, Aphanalides A-H, ring A-seco limonoids from the fruits of Aphanamixispolystachya. Tetrahedron 2012, 68 (21), 3963-3971.
33. Wang, J.S.; Zhang, Y.; Wang, X.B.; Wei, D.D.; Luo, J.; Luo, J.G.; Yang, M.H.; Yao, H.Q.; Sun, H.B.; Kong, L.Y.*, A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia. Tetrahedron Letters 2012, 53 (14), 1705-1709.
34. Wei, D.D.; Wang, J.S.*; Zhang, Y.; Kong, L.Y., A new phenylpropanoid glycoside from the fruits of Illicium simonsii. Chinese Journal of Natural Medicines 2012, 10 (1), 20-23.
35. Wei, D.D.; Wang, J.S.*; Kong, L.Y.*, Reversal effects of components from the fruits of Illicium simonsii on human adriamycin-resistant MCF-7 and 5-fluorouracil-resistant Bel7402 cells. Phytotherapy Research 2012, 26 (4), 562-567.
36. Wang, J.S.; Zhang, Y.; Wei, D.D.; Wang, X.B.; Luo, J.; Kong, L.Y.*, Novel tirucallane-type triterpenoids from Aphanamixis grandifolia. Chemistry & Biodiversity 2011, 8 (11), 2025-2034.
37. Yang, L.; Wei, D.D.; Chen, Z.; Wang, J.S.*; Kong, L.Y.*, Reversal effects of Traditional Chinese herbs on multidrug resistance in cancer cells. Natural Product Research, 2011, 25 (19), 1885-1889.
38. Yang, L.; Wei, D.D.; Chen, Z.; Wang, J.S.*; Kong, L.Y.*, Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine 2011, 18 (8-9), 710-718.
39. Wang, J.S.; Zhang, Y.; Luo, J.; Kong, L.Y.*, Complete 1H and 13C NMR data assignment of protolimonoids from the stem barks of Aphanamixis grandifolia. Magnetic Resonance in Chemistry 2011, 49 (7), 450-457.
