林原，博士，教授。林原于1982年7月于上海医科大学（现复旦大学上海医学院）获学士学位；1985年7月于上海第二医科大学（现上海交通大学医学院）获硕士学位；1992年6月于日本群马大学医学部获博士学位；1996年4月至1998年4月应日本学术振兴会的邀请赴日进行博士后研究。1998年起至今为大连医科大学教授，2000年起至今为博士生导师。
科研情况
（1）主持完成国家自然科学基金项目：（a）“平滑肌肌球蛋白活性的双向调节研究”,项目编号：No:30772601；（b）“肌球蛋白轻链激酶对肌球蛋白的非钙依赖性磷酸化研究”项目编号：30070203; （c）“肌球蛋白与肌动蛋白相互作用调节中的“双向调节”机制”, 项目编号：39670166。
研究方向
胃肠道药理学。胃肠道等重要器官的疾病与平滑肌功能变化密切相关。多种原因可造成平滑肌收缩舒张的失调。炎症、便秘、腹泻、收缩性的亢进与不足等症状皆可能交替存在互相影响。（1）不同于药物结构-效应之间的关系，也不同于由于存在作用相反化学成分或使用剂量不同所造成的双向调节，本研究室探讨肠平滑肌收缩状态决定药物的效应是兴奋性的或抑制性的规律性，为开发对于肠平滑肌收缩舒张具有双向调节的药物打下基础。（2）探讨药物对肠道炎症的缓解作用。
培养研究生情况
本研究已培养毕业博士生7名。研究组近5年来，研究生共发表SCI引用杂志发表文章19篇。其中，2013及2014毕业的两位博士研究生个人发表SCI累计影响因子皆在10分以上。本研究室毕业的研究生相当一部分目前任职在高校教学与科研岗位或成为知名公司的骨干，活跃于国际与国内科研教学岗位上。
代表性文章（* 通讯作者）
1. Xiong YJ, Chen DP, Yu CC, Lv BC, Peng JY, Wang JY, and Lin Y(林原，通讯)*. Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function. Mol Nutr Food Res. 2015, Feb 6 (已接受并已在PubMed 上发表). doi: 10.1002/mnfr.201400614.
2. Xiong YJ， Chen, D Peng JY, Wang, JY, Lv, BC, Liu FF, Lin, Y(林原，通讯)* Characteristics of evodiamine-exerted stimulatory effects on rat jejunal contractility. Nat Prod Res, 2015, 29: 388 - 391.
3. Yao, QY, Chen, DP, Ye, DM, Diao, YP, Lin, Y(林原，通讯)*. Modulatory effects of taurine on jejunal contractility. Braz J Med Biol Res, 2014, 47: 1068 -1074.
4. Chen DP, Xiong, YJ, and Lin Y(林原，通讯)*. Dual Role of MAPK Pathway in the Regulation of Intestinal Barrier Function. Inflamm Bowel Dis, 2014, 20: E16 - E16.
5. Xiong YJ, Chen, DP, Lv, BC; Liu, FF Yao, QY, Tang, ZY, Lin, Y(林原，通讯)*.Effects of ginsenoside Re on rat jejunal contractility. J Nat Med, 2014, 68: 530 - 538.
6. Xiong YJ, Chen DP, Lv BC, Liu FF, Wang Li, and Lin Y(林原，通讯)*. Characteristics of nobiletin-induced effects on jejunal contractility. Fitoterapia, 2014, 94: 1 - 9.
7. Liu FF, Chen, DP, Xiong, YJ Lv, BC, Lin, Y(林原，通讯)*. Characteristics of Diprophylline-Induced Bidirectional Modulation on Rat Jejunal Contractility. Korean J Physiol & Pha, 2014, 18: 47 - 53.
8. Chen DP, Xiong, YJ, Jiang CL, Lv BC, Liu FF, Wang L, Lin Y(林原，通讯)*. Effects of ginsenosides on rat jejunal contractility. Pharm Biol, 2014, 52: 162 - 168.
9. Chen, DP, Lin, Y (林原，通讯)*, X YJ. Epithelial MLCK and Smooth Muscle MLCK May Play Different Roles in the Development of Inflammatory Bowel Disease. Digest Dis Sci, 2014, 59: 1068 - 1069.
10. Zhang Y, Zhang, HL, Tang, ZY, Kohama, K, Lin, Y (林原，通讯)*. Inverse interaction between tropomyosin and phosphorylated myosin in the presence or absence of caldesmon. Acta Bioch Bioph Sin, 2013, 45 : 601 - 606.
11. Chen DP, Xiong YJ, Lv BC, Liu FF, Wang L, Tang ZY, Lin Y(林原，通讯)*. Effects of berberine on rat jejunal motility. J Pharm Pharmacol, 2013, 65:734-744.
12. Yao QY, Wang L, Du Z, Li K, Lin Y(林原，通讯)*. Characterization and biological evaluation of structurally modified taurine using benzaldehydes. Asian J Chem, 2013, 25: 7843 - 7846.
13. Ye DM, Zhang, HL, Wang L, Yao QY, Lin Y(林原，通讯)*., Li K. Synthesis, Crystal Structural and Activities of a New Schiff Base Derived from 2,4,5-Trimethoxybenzaldehyde. Asian J Chem, 2013, 25: 4629 - 4631.
14. Xiong YJ, Chen DP, Lv, BC, Liu, FF, Wang, L, Lin, Y. The characteristics of genistin-induced inhibitory effects on intestinal motility. Arch Phar Res, 2013, 36 : 345 - 352.
15. Chen DP, Xiong YJ, Tang ZY, Yao QY, Ye DM, Liu SS, Lin Y(林原，通讯)*. Characteristics of deslanoside-induced modulation on jejunal contractility. World J. Gastroentero, 2012, 18: 5889-5896. 10.3748/wjg.v18.i41.5889.
16. Chen DP, Xiong YJ, Wang L, Lv BC, Lin Y(林原，通讯)*.. Characteristics of emodin on modulating the contractility of jejunal smooth muscle. Can J Physiol Pharm, 2012, 90 : 455 - 462.
17. Chen DP, Xiong YJ, Tang ZY, Lv, BC, Lin Y(林原，通讯)*. Inhibitory effects of daidzein on intestinal motility in normal and high contractile states. Phar Biol, 2012, 50: 1561 - 1566.
18. Zhang Y, Tang, ZY, Kohama K, and Lin Y(林原，通讯)*. Interaction between myosin and a trace amount of caldesmon. J Biochem, 2011, 150: 267 - 270.
19. Tang ZY, Liu ZN, Fu L, Chen, DP, Ai QD, Lin Y. Effect of lithium on smooth muscle contraction and phosphorylation of myosin Light chain by MLCK. Physiol Res, 2010, 59: 919 - 926.
